Platelet proteomics

A central resource for platelet proteomics.

An impressive but bewildering array of data are now available, at the touch of a button, for every gene and protein in the human body. This information is the harvest of the so-called “omics” technologies, which began with the human genome sequencing project and gained from subsequent efforts to characterize the transcriptome, proteome, and metabolome of individual cell types. Those coming from...

Platelet Proteomics in Chronic Myeloid Leukemia

Platelet proteomics: identification of potential therapeutic targets.

The integration of proteomics into biochemical and biological investigation has proved a powerful tool in understanding the anucleate platelet. Over the past few years, various approaches have been used to document platelet proteins and here, we describe our efforts to analyse specific platelet subproteomes so as to capture biologically relevant proteins of low abundance. These include characte...

Platelet genomics and proteomics in human health and disease.

Proteomic and genomic technologies provide powerful tools for characterizing the multitude of events that occur in the anucleate platelet. These technologies are beginning to define the complete platelet transcriptome and proteome as well as the protein-protein interactions critical for platelet function. The integration of these results provides the opportunity to identify those proteins invol...

Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes.

Platelets, while anucleate, contain RNA, some of which is translated into protein upon activation. Hypothesising that the platelet proteome is reflected in the transcriptome, we identified 82 proteins secreted from activated platelets and compared these, as well as published proteomic data, to the transcriptional profile. We also compared the transcriptome of platelets to other tissues to ident...